A Simulation Method for Analyzing and Evaluating Rail System Performance Based on Speed Profile

This paper presents and discusses a simulation method for analyzing and evaluating system performance on a rail line from the perspective of speed profile. Dynamic analysis for train motions is introduced, and a discrete time-operation graph is proposed to represent the relation between speed profile and energy consumption. Based on them, an analytical model is formulated to provide a quick insight into the system performance. The discrete-time simulation (DTS) method is then implemented to study the system in detail. Compared to the existing simulations, two innovations are included in the DTS: (1) the analytical lookup tables that can simplify the dynamic computation and, (2) the speed profile adjustment process that forecasts and avoids future conflicts based on practical constraints. The numerical results show that the DTS speed profile has advantages over existing methods. Finally, the DTS method is used to analyze and evaluate the system performance of the current timetable on Beijing Yizhuang Metro Line. The results suggest that the current timetable is not robust enough, and thus possible improvements are discussed at both scheduling and operating stages. The proposed method is verified to be effective and reliable for practical uses.     

Effects of Fe_2O_3 on the properties of ceramics from steel slag

Ferric oxide is one of the key factors affecting both the microstructure and the properties of CaO-MgO-SiO_2-based ceramics. Research on this effect is significant in the utilization of iron-rich solid wastes in ceramics. Ceramic samples with various Fe_2O_3 contents(0 wt%, 5 wt%, and 10 wt%) were prepared and the corresponding physical properties and microstructure were studied. The results indicated that Fe_2O_3 not only played a fluxing role, but also promoted the formation of crystals. Ceramics with 5 wt% of Fe_2O_3 addition attained the best mechanical properties with a flexural strength of 132.9 MPa. Iron ions were dissolved into diopside, consequently causing phase transformation from diopside and protoenstatite to augite, thereby contributing to the enhancement of its properties. An excess amount of Fe_2O_3 addition(10 wt% or more) resulted in deteriorated properties due to the generation of an excess volume of liquid and the formation of high-porosity structures within ceramics.     

五味子有效成分保护心室重构的研究进展

五味子对心血管、免疫系统及CNS具有调节作用,阐述了五味子中有效成分木脂素和多糖保护心室重构的作用.     

ID-Based Public Auditing Protocol for Cloud Storage Data Integrity Checking with Strengthened Authentication and Security

Cloud storage service reduces the burden of data users by storing users’ data files in the cloud. But, the files might be modified in the cloud. So, data users hope to check data files integrity periodically. In a public auditing protocol, there is a trusted auditor who has certain ability to help users to check the integrity of data files. With the advantages of no public key management and verification, researchers focus on public auditing protocol in ID-based cryptography recently. However, some existing protocols are vulnerable to forgery attack. In this paper, based on ID-based signature technology, by strengthening information authentication and the computing power of the auditor, we propose an ID-based public auditing protocol for cloud data integrity checking. We also prove that the proposed protocol is secure in the random oracle model under the assumption that the Diffie-Hellman problem is hard. Furthermore, we compare the proposed protocol with other two ID-based auditing protocols in security features, communication efficiency and computation cost. The comparisons show that the proposed protocol satisfies more security features with lower computation cost.     

Attack and Defense Strategies in Complex Networks Based on Game Theory

To investigate the attack and defense strategies in complex networks, the authors propose a two-player zero-sum static game model with complete information which considers attack and defense strategies simultaneously. The authors assume that both the attacker and defender have two typical strategies: Targeted strategy and random strategy. The authors explore the Nash equilibriums of the attacker-defender game and demonstrate that when the attacker's attack resources are not so significantly abundant as the defender's resources, there exists a pure-strategy Nash equilibrium in both model networks and real-world networks, in which the defender protects the hub targets with large degrees preferentially, while the attacker prefers selecting the targets randomly. When the attack resources are much higher than defense resources, both the attacker and the defender adopt the targeted strategy in equilibriums. This paper provides a new theoretical framework for the study of attack and defense strategies in complex networks.     

Protein kinase D inhibitor CRT0066101 suppresses bladder cancer growth in vitro and xenografts via blockade of the cell cycle at G2/M

The protein kinase D (PKD) family of proteins are important regulators of tumor growth, development, and progression. CRT0066101, an inhibitor of PKD, has antitumor activity in multiple types of carcinomas. However, the effect and mechanism of CRT0066101 in bladder cancer are not understood. In the present study, we show that CRT0066101 suppressed the proliferation and migration of four bladder cancer cell lines in vitro. We also demonstrate that CRT0066101 blocked tumor growth in a mouse flank xenograft model of bladder cancer. To further assess the role of PKD in bladder carcinoma, we examined the three PKD isoforms and found that PKD2 was highly expressed in eight bladder cancer cell lines and in urothelial carcinoma tissues from the TCGA database, and that short hairpin RNA (shRNA)-mediated knockdown of PKD2 dramatically reduced bladder cancer growth and invasion in vitro and in vivo, suggesting that the effect of the compound in bladder cancer is mediated through inhibition of PKD2. This notion was corroborated by demonstrating that the levels of phospho-PKD2 were markedly decreased in CRT0066101-treated bladder tumor explants. Furthermore, our cell cycle analysis by flow cytometry revealed that CRT0066101 treatment or PKD2 silencing arrested bladder cancer cells at the G2/M phase, the arrest being accompanied by decreases in the levels of cyclin B1, CDK1 and phospho-CDK1 (Thr161) and increases in the levels of p27^Kip1 and phospho-CDK1 (Thr14/Tyr15). Moreover, CRT0066101 downregulated the expression of Cdc25C, which dephosphorylates/activates CDK1, but enhanced the activity of the checkpoint kinase Chk1, which inhibits CDK1 by phosphorylating/inactivating Cdc25C. Finally, CRT0066101 was found to elevate the levels of Myt1, Wee1, phospho-Cdc25C (Ser216), Gadd45α, and 14-3-3 proteins, all of which reduce the CDK1-cyclin B1 complex activity. These novel findings suggest that CRT0066101 suppresses bladder cancer growth by inhibiting PKD2 through induction of G2/M cell cycle arrest, leading to the blockade of cell cycle progression.     

An Additive-Multiplicative Cox-Aalen Subdistribution Hazard Model for Competing Risks Data

This paper proposes a flexible additive-multiplicative Cox-Aalen hazard model which allows time-varying covariate effects for the subdistribution in a competing risks study. Weighted estimating equation approaches under an covariates-dependent adjusted weight by fitting the Cox proportional hazard model for the censoring distribution are established for inference on the model parametric and nonparametric components. In addition, large number properties are presented and the finite sample behavior of the proposed estimators is evaluated through simulation studies, estimators from the proposed method perform satisfactorily on reduction of the bias. The authors apply our model to a competing risks data set from a tamoxifen trail for breast cancer study.     

The Life-Cycle Model with Optimal Retiring Age and Simulation

In this paper, a life-cycle model with retirement is set up to study how an individual chooses the optimal retiring age on account of wage growth rate, longevity and healthy state. It is proved that there exists optimal retiring age under given conditions. The numerical simulations are given to show how wage growth rate, longevity and healthy state affect retiring age.     

液晶清亮点对光敏手性偶氮苯分子螺旋扭曲力常数的影响

本文主要研究了光敏手性偶氮苯分子Azo-o-Bi的螺旋扭曲力常数(β)及其变化量(Δβ)与液晶清亮点之间的关系。将光敏手性偶氮苯分子Azo-o-Bi与不同的向列相液晶主体E7,HTG135200-100,HNG715600-100配置成具有光敏性的胆甾相液晶,测量Azo-o-Bi分子在不同胆甾相液晶中的β值及Δβ值。通过分析不同胆甾相液晶的差热扫描量热(DSC)曲线,研究手性剂的β值及Δβ值与液晶清亮点间的关系。发现液晶的清亮点越高,手性剂的β值及Δβ值越大。这是由于液晶清亮点越高,其所对应的有序度参数越大,液晶分子排列的有序程度越高,分子间的相互作用力越强,从而导致光敏手性剂对向列相液晶产生的螺旋扭曲力及其变化量就越大。     

An Improved Underwater Confrontation Simulation Method of Naval Amphibious Operational Training System

This paper described an improved underwater confrontation simulation method of naval amphibious operational training system. The initial position of submarine forces on the enemy is generated automatically, and the attacking distance model of torpedoes is established based on the kinematics theory, which is more flexible and reasonable to judge the launch condition compared to traditional method. The two kinds of confrontation behavior models on the enemy submarine are created to depict its tactical action from the defensive to the offensive as well as the contrary, ensuring that operational style is simulated more comprehensively and properly. The existing motion trajectory estimation and collision detection algorithms on operational platforms are also improved to reduce the iteration error and further enhance the detection accuracy of target hit.